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Grape extracts may protect against colon cancer.

Colon cancer is a very common form of cancer, affecting tens of thousands of people across the United States. Researchers may have just moved closer to a prevention strategy for this condition, as a compound that suppresses colon cancer stem cells is found in grapes.

In the U.S., colorectal cancer is the third leading cause of death from cancer among women and the second in men.

The American Cancer Society estimate that in 2017, more than 95,500 people will develop cancer of the colon, almost 40,000 people will have rectal cancer, and more than 50,000 deaths will be caused by colorectal cancer.

A team of researchers led by Jairam K. P. Vanamala, associate professor of food sciences at the College of Agricultural Sciences at Pennsylvania State University in State College, set out to examine the effects of grape compounds on colon cancer stem cells.

More specifically, the researchers tested the effect of a combination of resveratrol – a polyphenolic compound found in grapes, red wine, peanuts, and some berries – and grape seed extract.

As the authors write, the study rests on the theory that “most, if not all, cancerous tumors are driven by [cancer stem cells].”

“Cancer stem cells are capable of self-renewal, cellular differentiation, and maintain their stem cell-like characteristics even after invasion and metastasis,” explains lead researcher Prof. Vanamala.

The findings were published in the journal BMC Complementary and Alternative Medicine.
Grape extracts halved cancer tumors

Prof. Vanamala and colleagues examined 52 mice with colon cancer tumors. They divided the rodents into three groups: one group was fed the grape compound combination, another group was fed sulindac (an anti-inflammatory drug previously found to reduce tumors in humans), and one group was given a normal diet.

The researchers found that the number of tumors in the mice that had the grape compound diet decreased by 50 percent. This drop was similar to the one seen in the sulindac group, but unlike the anti-inflammatory drug, the grape compounds did not cause any gastrointestinal toxicity.

Continues at: http://www.medicalnewstoday.com/articles/318007.php

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