Study reveals how diabetes drug promotes healthy aging

Doctors commonly prescribe metformin to help people with type 2 diabetes lower their blood sugar levels. The drug increases insulin sensitivity through its effects on glucose metabolism.

However, although there is clear evidence of metformin’s effectiveness, scientists do not fully understand how it interacts with cells and tissues at the molecular level.

Now, a new Cell Reports study has mapped metformin activity in the liver and yielded some surprising results.

Using cell cultures and mice, the researchers identified numerous biochemical switches for turning various cell and molecular processes on and off.

The findings shed light not only on metformin’s mechanism of glucose control, but also on a surprising number of other reactions and pathways.

The researchers suggest, for instance, that the new findings could help explain recent revelations about metformin’s apparent ability to promote healthy aging.

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